Chromatin modification by DNA tracking
نویسندگان
چکیده
منابع مشابه
Transcriptional control: Repression by local chromatin modification
It is becoming increasingly clear that chromatin modification plays a fundamental part in transcriptional control. Recent studies provide new insights into how transcriptional repressors, in addition to blocking activators, may recruit repression complexes that include chromatin modification factors.
متن کاملChromatin modification and disease.
“Physicians consider that when they have discovered the cause of disease, they have also discovered the method of treating it.” Cicero, Tusculan Disputations, III.x.23. In the last few years, the exciting realisation in the field of gene regulation is that transcription factors can function by recruiting large, multiprotein complexes which mediate several types of chromatin modification and rem...
متن کاملModification of DNA bases in chromatin of intact target human cells by activated human polymorphonuclear leukocytes.
We investigated whether phorbol-12-acetate-13-myristate (PMA)-activated human polymorphonuclear leukocytes (PMNs) induce base modifications in target cell DNA in vivo. Human PMNs produced 9.4 +/- 0.8 (SD) nmol of H2O2/10(6) cells during 50 min of exposure to 2 micrograms/ml PMA and 13.7 +/- 2.8 nmol/10(6) cells during exposure to PMA plus 5 mM NaN3. Neither nonstimulated PMNs, nor PMA alone, no...
متن کاملDistribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break
BACKGROUND In response to DNA double-strand breaks (DSBs), eukaryotic cells rapidly phosphorylate histone H2A isoform H2AX at a C-terminal serine (to form gamma-H2AX) and accumulate repair proteins at or near DSBs. To date, these events have been defined primarily at the resolution of light microscopes, and the relationship between gamma-H2AX formation and repair protein recruitment remains to ...
متن کاملModification of DNA Bases in Chromatin of Intact Target Human Cells by Activated Human Polymorphonuclear Leukocytes1
We investigated whether phorbol-12-acetale-13-myristate (PMA)-activated human polymorphonuclear leukocytes (PMNs) induce base modifi cations in target cell DNA in vivo. Human PMNs produced 9.4 ±0.8 (SD) ninol of l M >71(>''cells during 50 min of exposure to 2 ug/ml I'M A and 13.7 ±2.8 iiini)l/l(l'' cells during exposure to I'M V plus 5 uni N;iN,. Neither nonstimulated PMNs, nor PMA alone, nor...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.24.13634